5 Amino 1MQ ua dab tsi?
cov 5-Amino-1MQ compound, uas yog me me, xaiv, thiab tuaj yeem dhau los ntawm cov cell membranes, lub hom phiaj cuam tshuam rau cov kab ke tshwj xeeb uas tswj cov roj cia, cov leeg nqaij, thiab cov metabolism. Cov kws tshawb fawb thawj zaug tsim 5-Amino-1MQ los kawm txog cov txheej txheem metabolic txuas rau kev rog rog thiab muaj hnub nyoog txog cov teeb meem metabolic.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales4@faithfulbio.com
Luv Lus Qhia Txog
"5-Amino-1MQ (NNMTi)" yog peptide uas tuaj yeem ua rau lub cev muaj zog thiab muaj txiaj ntsig zoo rau kev hlawv rog thiab rog rog. Qhov laj thawj yog vim li cas "5-Amino-1MQ" zoo rau kev noj zaub mov yog tias nws tuaj yeem ua rau nce qhov concentration ntawm NAD (nicotinamide adenine dinucleotide), thiab NAD yog ib yam khoom tseem ceeb rau kev noj qab haus huv ntawm tes thiab kev ua haujlwm hauv lub cev. NNMTi yog ib qho zoo inhibitor ntawm nicotinamide N-methyltransferase (NNMT) (IC50 = 1.2μM), thiab tuaj yeem xaiv khi rau cov seem ntawm NNMT substrate binding site. NNMTi tuaj yeem txhawb nqa qhov sib txawv ntawm myoblasts hauv vitro thiab txhim kho kev sib xyaw thiab kev tsim muaj peev xwm ntawm cov leeg qia hlwb hauv cov nas hnub nyoog.
Melting point: 213-214 ° C.
Cov mis mos molecular: C10H11IN2
Molecular phaus: 286.11
Txoj kev npaj
5-Amino-1Mq yog ib qho me me molecule inhibitor ntawm nicotinamide N-methyltransferase (NNMT), uas tau kawm dav hauv xyoo tas los. Hais txog kev npaj cov tshuaj no, feem ntau muaj ob txoj kev siv hluavtaws tau hais hauv cov ntaub ntawv tam sim no: Ib qho yog cov tshuaj tiv thaiv ncaj qha ntawm 5-Aminoquinoline nrog Iodomethane hauv Isopropyl cawv. Qhov tsis zoo ntawm cov tshuaj tiv thaiv no yog qhov tsis tshua muaj txiaj ntsig. Lwm qhov yog cov tshuaj tiv thaiv ntawm 5-Aminoquinoline thiab Iodomethane los ua 5-Amino-1Mq, uas yog tom qab ntawd tau los ntawm kev txo cov hmoov hlau. Qhov tsis zoo ntawm cov tshuaj tiv thaiv no yog tias cov khoom rho tawm yog qhov nyuaj, thiab cov dej khib nyiab loj heev, ua rau muaj kuab paug ib puag ncig loj. Yog li ntawd, nws yog ib qho tseem ceeb tshwj xeeb rau kev tshawb nrhiav cov txheej txheem hluavtaws uas yog ntsuab, ib puag ncig tus phooj ywg, yooj yim rau kev khiav lag luam, kev lag luam thiab kev nyab xeeb.
Raws li qhov tsis txaus ntawm cov cuab yeej technology uas twb muaj lawm, qhov kev tsim kho tam sim no muab cov txheej txheem synthesis ntawm 5-Amino-1Mq, suav nrog cov kauj ruam hauv qab no: Ntxiv 5-Aminoquinoline thiab cov tshuaj tiv thaiv hnyav rau lub reactor thiab do; Dissolve Iodomethane nyob rau hauv cov tshuaj tiv thaiv hnyav, ntxiv nws dropwise rau lub reactor. Tom qab qhov sib ntxiv ntawm dropwise tiav, nce qhov kub thiab tswj qhov ntsuas kub, tom qab ntawd txias thiab txuas ntxiv mus do, lim, thiab yaug lub ncuav mog qab zib lim nrog me me ntawm cov tshuaj tiv thaiv hnyav. Tom qab purifying lub ncuav mog qab zib lim, nws yog ntxuav thiab qhuav kom tau ib tug reddish-xim av khoom. Hauv qhov kev tsim no, cov khoom lag luam tau txais los ntawm cov tshuaj tiv thaiv ncaj qha ntawm 5-Aminoquinoline thiab Iodomethane. Los ntawm optimizing cov tshuaj tiv thaiv tej yam kev mob, cov ntsiab lus ntawm lub hom phiaj cov khoom nyob rau hauv cov tshuaj tiv thaiv system tau nce, thiab purification tej yam kev mob ntawm cov khoom raug tshawb nrhiav. Ua kom purity ntawm 5-Amino-1Mq muaj peev xwm ncav cuag ntau dua 99%.
Kev tshawb fawb ntsig txog
Kev rog rog yog ib qho teeb meem loj thiab muaj kev noj qab haus huv thoob ntiaj teb, thiab muaj ob peb txoj kev kho mob zoo. Txoj kev tshawb no tshawb xyuas cov txiaj ntsig ntawm metabolic thiab physiological ntawm kev sib xyaw ntawm 5-Amino-1Mq (NNMTi) kev kho mob thiab kev noj zaub mov hloov hauv kev noj cov nas rog rog. Piv nrog rau kev txhim kho kev noj zaub mov yooj yim, 5-Amino-1Mq kev kho mob ua ke nrog kev noj zaub mov hloov tuaj yeem ua kom lub cev hnyav thiab rog, nce qhov sib piv ntawm lean lub cev hnyav rau lub cev hnyav, txo qhov hnyav ntawm cov nqaij dawb adipose hauv daim siab thiab epididymis, txo daim siab rog, thiab txhim kho daim siab steatosis los ntawm ib tus neeg hloov. Qhov tseem ceeb, kev sib xyaw ua ke ntawm ob tuaj yeem normalize lub cev muaj pes tsawg leeg thiab daim siab rog rog. 5-Amino-1Mq kev kho mob tau tsim cov yam ntxwv metabolomic nyob rau hauv cov ntaub so ntswg adipose, feem ntau yog ua kom cov nplua nuj ntawm ketogenic amino acids thiab cov kev hloov hauv cov metabolites cuam tshuam rau lub zog metabolism txoj hauv kev. Tag nrho cov nyob rau hauv tag nrho cov, cov kev cai ntawm lub cev hnyav, rog rog, daim siab physiology thiab adipose cov ntaub so ntswg metabolome los ntawm 5-Amino-1Mq kev kho mob txhawb nws raws li ib tug cog lus kev kho mob mus kom ze rau kev rog thiab rog-induced teeb meem.
Tsis tas li ntawd, 5-Amino-1Mq (NNMTi) kuj tuaj yeem txhim kho lub zog thiab txhawb nqa lub peev xwm ntawm cov leeg nqaij laus, yog li muab txoj kev kho mob zoo rau sarcopenia. Cov kev tshawb fawb tau pom tias 5-Amino-1Mq kev kho mob tuaj yeem tsis tsuas yog txhawb nqa kev txhim kho kom muaj nuj nqis ntawm lipid cov ntsiab lus hauv cov leeg nqaij, tab sis kuj tseem ua rau cov nqaij ntshiv plab zom mov zoo thaum ua ke nrog kev tawm dag zog. Cov tshuaj raws li 5-Amino-1Mq, txawm tias siv ib leeg lossis ua ke nrog kev tawm dag zog, yuav muaj txiaj ntsig zoo rau kev kho mob sarcopenia thiab ntau yam muaj hnub nyoog txog myopathies.
Dab tsi yog 5 amino 1MQ ntxiv?
5-Amino-1MQ yog cov molecule me me uas muaj peev xwm tseem ceeb hauv kev noj qab haus huv thiab kev noj qab haus huv. Nws yog cais raws li ib tug derivative ntawm methylquinolinium. Qhov tshwj xeeb zoo li peptide no tau txais kev saib xyuas rau nws lub luag haujlwm hauv kev txhawb nqa cov metabolism, tswj qhov hnyav, thiab cellular zog tsim.
Puas yog 5 Amino 1MQ phiv?
Puas muaj kev phiv? Cov tshuaj twg tuaj yeem muaj cov kev mob tshwm sim, tab sis cov ntawm 5 Amino 1MQ yog tsawg. Hives lossis ua xua tuaj yeem ua tau nrog cov peptide no.
1. Koj puas muaj teeb meem xa tuaj rau kuv lub tebchaws?
A: Peb muaj warehouses nyob teb chaws Europe, America thiab Australia. Nyob rau tib lub sijhawm, yog tias koj tuaj ntawm Tebchaws Europe, cov khoom tuaj yeem xa los ntawm lub teb chaws Yelemees, thiab yog tias koj los ntawm Asmeskas lossis Canada, cov khoom tuaj yeem xa los ntawm California.
2. Cov khoom ntim li cas?
A: Peb feem ntau xa cov khoom nrog cov khoom pov tseg sab nraud thiab ob txheej txheej sterile pob tshab hauv lub hnab.Peb tau sim ntau txhiab txoj hauv kev, nws zoo li hnyav thiab tsis pom kev.
3. Thaum twg koj yuav xa cov khoom tom qab them nyiaj tiav?
A: Feem ntau qhov kev txiav txim yuav xa tuaj tsis pub dhau 2-3 hnub tom qab qhov kev txiav txim tau lees paub, tshwj tsis yog cov khoom lag luam customized.
4. Yuav ua li cas mus txiav txim?
A: Thov cia kuv paub cov khoom koj tab tom nrhiav, kom muaj nuj nqis thiab lub teb chaws qhov chaw uas pab kuv muab tus nqi tsim nyog; Tom qab koj paub meej tias tag nrho cov ntsiab lus ntawm kev txiav txim, them nyiaj ua ntej thiab muab qhov chaw nyob Shipping rau peb.Peb npaj cov khoom xa tuaj thaum thawj zaug tom qab tau txais cov nyiaj them poob haujlwm thiab muab kev pab cuam tom qab muag tom qab koj tau txais parcel.
Xa koj Cov Lus Nug kom paub meej ntxiv, Nyem email:sales4@faithfulbio.com
